Role of lipid peroxidation in serotonin receptor injury and onset of epileptiform seizures during hyperoxia
| Autor: | Valerian E. Kagan, V. M. Savov, Prilipko Ll, R. A. Kopaladze |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Hyperoxia
medicine.medical_specialty Chemistry General Medicine Brain damage Serotonergic General Biochemistry Genetics and Molecular Biology Lipid peroxidation chemistry.chemical_compound Serotonin binding Endocrinology Biochemistry Internal medicine medicine Serotonin medicine.symptom Receptor 5-HT receptor |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 96:1664-1667 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Epileptiform seizures are a characteristic manifestation of the toxic action of oxygen (hyperoxia) on the brain [9, 13]. An essential role in seizure formation can be played by damage to the serotoninergic system of the brain [7]. However, the concrete mechanisms through which injury to this system in hyperoxia is realized have not yet been discovered [2]. Two groups of facts obtained recently accordingly appear to be important: i) intensification of generation of active forms of oxygen during hyperbaric oxygenation [12, 13], which can activate lipid peroxidation (LPO) in membrane structures of the brain [3], 2) the ability of LPO products to lower the level of binding of [mH] serotonin with receptors in brain microsomal fraction in vitro [15]. The following hypothetical chain of events, essential for the pathogenesis of hyperoxygenation brain damage and the appearance of epileptiform seizures can be submitted on the basis of these findings: increased p02 § increased concentration of active forms of oxygen (0~, "OH) § activation of LPO § inhibition of serotonin binding with receptors § disturbances of function. |
| Databáze: | OpenAIRE |
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