Study on ligation of copper complexes of the quinolone antibacterial drugs and octamolybdates POMs
| Autor: | Pengfei Yan, Cheng Wang, Li-Ye Liang, Jing-Quan Sha, Guangming Li, Dong-Yun Ma |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
chemistry.chemical_classification
Chemistry medicine.drug_class Stereochemistry Protein subunit Supramolecular chemistry chemistry.chemical_element Quinolone Copper Inorganic Chemistry Covalent bond Materials Chemistry medicine Non-covalent interactions Molecule Physical and Theoretical Chemistry Single crystal |
| Zdroj: | Polyhedron. 31:422-430 |
| ISSN: | 0277-5387 |
| DOI: | 10.1016/j.poly.2011.09.029 |
| Popis: | By introducing different quinolone antibacterial drugs into the octamolybdates POMs, four new compounds, [CuII(L1)2(H2O)2]H2[β-Mo8O26]·4H2O (1), [CuII2(L2)4][δ-Mo8O26]·4H2O (2), [CuII2(L3)2(H2O)2][β-Mo8O26] (3), [CuII2(L4)2(H2O)4][β-Mo8O26]·2H2O (4) (where L1 = Enrofloxacin; L2 = Pipemidic Acid; L3 = Norfloxacin; L4 = Enoxacin), have been synthesized and characterized by routine physical methods and single crystal X-ray diffraction. In compound 1, isolated Cu–Enrofloxacin coordination subunits array the both sides of β-Mo8O26, forming 3D supramolecular structure via noncovalent interactions. And the Cu–Pipemidic Acid subunits covalently link δ-Mo8O26 to form 3D supramolecular structures via short interactions in 2. In 3, the Cu–Norfloxacin motif exhibits 1D chain structure, and the tetra-dentate β-[Mo8O26]4− clusters interact with neighboring chains to construct a 2D sheet. Similar to that of 3, the Cu–Enoxacin subunit in 4 exhibits 1D chain structure, and the bi-dentate β-[Mo8O26]4− clusters interact with neighboring chains to construct a 2D sheet. Due to the introduction of different drug molecules, the octamolybdates POMs exhibit different isomers and structures, which bring different properties. The antitumor activities of compounds 1–4 in vitro were studied by MTT experiments, and the results show that introduction of different drug molecules onto the polyoxoanion surface can affect their antitumor activities. |
| Databáze: | OpenAIRE |
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