Vitamin C im Langzeitversuch ohne Einflu� auf die experimentelle Carcinogenese

Autor:	H. Schäfer, K. Hrynyschyn, B. Werner
Rok vydání:	1985
Předmět:	medicine.medical_specialty Vitamin C Histological type business.industry Ascorbic acid medicine.disease_cause medicine.disease Small intestine Surgery medicine.anatomical_structure Endocrinology Internal medicine medicine Carcinoma Carcinogenesis business
Zdroj:	Langenbecks Archiv f�r Chirurgie. 363:185-193
ISSN:	1435-2451 0023-8236
DOI:	10.1007/bf01261292
Popis:	This long-term study deals with the effect of ascorbic acid on chemically induced carcinogenesis of the small intestine in rats. Carcinoma was induced in 27 animals by application of N-Ethyl-N′-nitro-N-nitrosogua-nidine (ENNG) alone in the drinking water (120 mg/1). The average survival time was 238 (± 40) days. The addition of large amounts of ascorbic acid to the food (3 g/100 g food) did not suppress the development of tumors. On the contrary, a significant reduction in the survival time was seen. All animals receiving ENNG and ascorbic acid only lived 207 (± 45) days on average. Neither histological type of tumor spread was influenced by the use of ascorbic acid. Giving ascorbic acid alone had no effect on the survival time and did not lead to changes in the tissue of the small intestine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a244e30b01819adb50fc2f10d09d398 https://doi.org/10.1007/bf01261292 Zobrazit plný text záznamu Full text from SpringerLink