Analysis of lipids and dioxin in chloracne due to tetrachloro-2,5,7,8-p-dibenzodioxin

Autor:	M. Nazzaro-Porro, Siro Passi, L Boniforti, Ferdinando Gianotti
Rok vydání:	1981
Předmět:	medicine.medical_specialty Polychlorinated dibenzodioxins Thin layer Dermatology medicine.disease Molecular biology Squamous metaplasia Epithelium Chloracne chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine
Zdroj:	British Journal of Dermatology. 105:137-143
ISSN:	1365-2133 0007-0963
DOI:	10.1111/j.1365-2133.1981.tb01198.x
Popis:	Biochemical investigations on the lipid and dioxin content of the cysts and comedo-like lesions of three children exposed to tetrachloro-2,3,7,8-p-dibenzodioxin (TCDD) have been performed. Gas chromatography and mass spectrometry failed to demonstrate the presence of dioxin despite the high sensitivity of the method. Further investigation by thin layer and gas chromatography-mass spectrometry showed that the lipids of the chloracne lesions in these children were exclusively epidermal in origin. These findings support the hypothesis that exposure to dioxin produces a hyperproliferative reaction of the cutaneous epithelium with squamous metaplasia of the cells lining the ducts of skin glands.
Databáze:	OpenAIRE
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