Effects of isopentenyl adenosine and phytohemagglutinin upon RNA syntheses in lymphocytes
| Autor: | Bruce Hacker, T. L. Feldbush |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Cancer Research
RNA Spleen Methylation Biology bacterial infections and mycoses Molecular biology Adenosine In vitro respiratory tract diseases chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry Biochemistry In vivo medicine skin and connective tissue diseases DNA Antibody formation medicine.drug |
| Zdroj: | Cancer. 27:1384-1387 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(197106)27:6<1384::aid-cncr2820270618>3.0.co;2-f |
| Popis: | N6-(δ2-isopentenyl) adenosine (iPA) has been previously shown to inhibit DNA and RNA synthesis in cultured lymphocytes and to suppress antibody formation in vivo. The effects have been extended to show that iPA has little preferential action on phytohemagglutinin-transformed spleen cells in vitro. Finally, iPA is found to alter the methylation of all species of RNA but in a disproportionate manner in either PHA-transformed or non-stimulated lymphocytes. |
| Databáze: | OpenAIRE |
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