Comparison of the tissue response during the loading with voltage-sensitive dye in two animal models
| Autor: | Ivo Provaznik, M. Blaha, J. Bardonova, Marie Nováková |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
0303 health sciences
medicine.medical_specialty medicine.diagnostic_test Chemistry Voltage-sensitive dye Hemodynamics Washout 030204 cardiovascular system & hematology Guinea pig 03 medical and health sciences Electrophysiology 0302 clinical medicine Internal medicine Optical mapping Heart rate medicine Cardiology sense organs skin and connective tissue diseases Electrocardiography 030304 developmental biology |
| Zdroj: | Computers in Cardiology, 2005. |
| DOI: | 10.1109/cic.2005.1588156 |
| Popis: | Two animal models - guinea pig and rabbit - were used to record monophasic action potentials using voltage sensitive dye di-4-ANEPPS in isolated hearts perfused according to Langendorf. The hearts undergo the same isolation and loading procedures. Changes in electrogram and coronary flow are followed. During the loading and washout, prominent electrophysiological changes occur (mainly decrease of spontaneous heart rate and changes in the shape of T wave), accompanied with decrease in mean coronary flow. However, these changes differ in the two species. It may be concluded that rabbit heart is more resistant to the changes which are triggered with VSD application. Although these changes are partially reversible in guinea pig heart, this model seems to be more sensitive and thus less reliable |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|