Systéme lymphocytaire et résistance relative de la souris consanguine a Trypanosoma brucei brucei
| Autor: | P. De Baetselier, A M Makumyaviri, M Sileghem, Raymond Hamers, D. Le Ray |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
education.field_of_study
medicine.diagnostic_test biology Lymphocyte Population Spleen General Medicine T lymphocyte Trypanosoma brucei Immunofluorescence biology.organism_classification medicine.disease Virology medicine.anatomical_structure Lymphatic system parasitic diseases medicine General Earth and Planetary Sciences education Trypanosomiasis General Environmental Science |
| Zdroj: | Annales de l'Institut Pasteur / Immunologie. 139:545-556 |
| ISSN: | 0769-2625 |
| DOI: | 10.1016/0769-2625(88)90099-2 |
| Popis: | The distribution of B-(Ig+) and T-(Thy1.2+, Lyt1+, Lyt2+) lymphocyte subsets in murine lymphoid organs was analysed by immunofluorescence (FACS) on cell suspensions throughout a primary infection of C3H/He (susceptible) and CBA/Ca (subtolerant) inbred mice with metacyclic Trypanosoma brucei brucei EATRO 1125. A direct correlation was observed between (1) the level of first-peak parasitaemia, (2) its subsequent control by the host and (3) survival time. In the course of the infection, the overall population of spleen and lymph node lymphocytes was subject to polyclonal activation whilst the proportion of differentiated B and T subsets decreased accordingly. No correlation was found between modulation of the lymphocyte system and susceptibility to trypanosomiasis. |
| Databáze: | OpenAIRE |
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