ChemInform Abstract: A Simple and Regioselective One-Pot Procedure for the Direct N-Acylation of Some Purine and Pyrimidine Nucleobases via Carboxylic Acids Using Cyanuric Chloride

Autor:	Somayeh Behrouz, Mohammad Navid Soltani Rad, Ali Khalafi-Nezhad, Zeinab Asrari
Rok vydání:	2015
Předmět:	Purine chemistry.chemical_compound Pyrimidine N acylation Chemistry Cyanuric chloride Purine derivative Regioselectivity General Medicine Combinatorial chemistry Nucleobase
Zdroj:	ChemInform. 46
ISSN:	0931-7597
Popis:	A facile and selective one-pot N-acylation of nucleobases via carboxylic acids using cyanuric chloride (2,4,6-trichloro-1,3,5-triazine) is described. In this protocol, the reaction of diverse carboxylic acids with pyrimidine and/or purine nucleobases is efficiently achieved in the presence of cyanuric chloride and NaH/Et3N in DMF/MeCN (1:1, v/v) to afford the corresponding N-acyl nucleobases in good yields.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::3a1053e6bea2fb347fef55762b2669f7 https://doi.org/10.1002/chin.201521194 Zobrazit plný text záznamu Plný text