Oligo- and macrocyclic diterpenes in thymelaeaceae and euphorbiaceae occurring and utilized in yunnan (Southwest China) 4. Tigliane type diterpene esters (phorbol–12,13-diesters) fromWikstroemia canescens

Autor:	E. H. Seip, B. Sorg, H. J. Opferkuch, E. Hecker, W. Adolf, Wu Dagang
Rok vydání:	1993
Předmět:	Pharmacology biology Traditional medicine Stereochemistry Euphorbiaceae Wikstroemia canescens biology.organism_classification Phorbol ester chemistry.chemical_compound chemistry Phorbol Phorbol esters Thymelaeaceae Diterpene Wikstroemia
Zdroj:	Phytotherapy Research. 7:194-196
ISSN:	1099-1573 0951-418X
Popis:	From a methanol extract of the roots of Wikstroemia canescens (Wall) Meisen the hitherto unknown Wikstroemia factors C 1 and C 2 were isolated by means of a Craig distribution followed by TLC. They were identified as the tigliane type phorbol-12-benzoate-13-decanoate (C 2 ) and the corresponding -13-(3E, 5E-decadienoate) (C 1 ). On the mouse ear Wikstroemia factor C 1 showed irritant activity comparable to that of the standard irritant phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Wikstroemia factor C 2 , not assayed for irritancy, may be expected to be about as active as C 1
Databáze:	OpenAIRE
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