Does chronic smoking influence fibrinolytic potential in Type 1 diabetes mellitus?
| Autor: | A. J. Simpson, Nuala A. Booth, N. R. Moore, R. S. Gray |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Type 1 diabetes business.industry Endocrinology Diabetes and Metabolism Insulin medicine.medical_treatment medicine.disease respiratory tract diseases chemistry.chemical_compound Endocrinology Insulin resistance chemistry Plasminogen activator inhibitor-1 Internal medicine Diabetes mellitus Fibrinolysis behavior and behavior mechanisms Internal Medicine medicine Platelet business Plasminogen activator |
| Zdroj: | Diabetic Medicine. 15:683-687 |
| ISSN: | 1096-9136 0742-3071 |
| DOI: | 10.1002/(sici)1096-9136(199808)15:8<683::aid-dia643>3.0.co;2-e |
| Popis: | Tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI-1) were studied in 18 smokers and 18 closely matched non-smokers, all of whom had Type 1 diabetes mellitus (DM). None of the patients had advanced complications of diabetes. The t-PA and PAI-1 antigen levels were measured in plasma before and after venous occlusion, and were normal in Type 1 diabetes regardless of smoking status. Platelet PAI-1 levels were also measured and were found to be normal both in smokers and non-smokers. In smokers with Type 1 DM, plasma PAI-1 was significantly correlated with triglycerides. The normal fibrinolytic potential found in smokers with diabetes contrasts starkly with the significantly elevated plasma PAI-1 reported in smokers without diabetes. In smokers, triglycerides may effect low levels of PAI-1 release into plasma; this process may be significantly augmented in the presence of smoking-induced insulin resistance. The lack of endogenous insulin release in Type 1 diabetes may obviate the characteristic rise in plasma PAI-1 found in smokers who do not have diabetes. |
| Databáze: | OpenAIRE |
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