Lamotrigine in bipolar affective disorder
| Autor: | David Taylor, H W McConnell, Denise Duncan |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Second-line therapy
medicine.medical_specialty MEDLINE Lamotrigine medicine.disease 030227 psychiatry 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine Hypomania Rapid cycling medicine 030212 general & internal medicine Bipolar disorder medicine.symptom Psychology Psychiatry Mania Depression (differential diagnoses) Clinical psychology medicine.drug |
| Zdroj: | Psychiatric Bulletin. 22:630-632 |
| ISSN: | 1472-1473 0955-6036 |
| DOI: | 10.1192/pb.22.10.630 |
| Popis: | Aims and methodThe study aimed to assess the available data on the use of lamotrigine as a mood stabilising agent. We reviewed all published and unpublished data available to us through a Medline search from 1987–1998 and from our own files, which include reference materials presented at conferences as well as published reports.ResultsMost of the data found were derived from case reports or open trials. We could find no published double-blind, placebo-controlled studies. The data from initial open trials suggest that lamotrigine may be effective in bipolar disorder, but futher data are required before specific treatment recommendations can be made.Clinical implicationsAt this early stage, there are too few data to recommend lamotrigine for first or second line therapy in bipolar disorder. However, initial reports are very promising and this agent may eventually be unequivocally shown to be useful in treating mania, hypomania, depression, rapid cycling and mixed affective states in people with bipolar disorder. |
| Databáze: | OpenAIRE |
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