Microglia activation induced by serum of SLE patients
| Autor: | Jianing Wang, Yujia Li, Qi Zhao, Pingting Yang, Ziwei Zhu, Chunshu Yang |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
medicine.medical_treatment Immunology Major histocompatibility complex Nitric oxide Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine immune system diseases Immunology and Allergy Medicine skin and connective tissue diseases Neuroinflammation CD86 biology Microglia business.industry 030104 developmental biology Cytokine medicine.anatomical_structure Neurology chemistry biology.protein Tumor necrosis factor alpha Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Neuroimmunology. 310:135-142 |
| ISSN: | 0165-5728 |
| Popis: | To investigate the potential involvement of microglia in the neuropathology of systemic lupus erythematosus (SLE), we examined whether SLE patient sera could activate BV2 microglia in vitro. Exposure to SLE patient sera resulted in morphological changes in the microglia, an increase in MHC II and CD86 protein expression, and an obvious release of nitric oxide and proinflammatory cytokines. However, the SLE sera did not induce a specific change in the production of immunoregulatory cytokines. Inactivating complements or neutralizing proinflammatory cytokines in the SLE sera did not suppress microglial activation. Our results highlight the potential role of microglia in neuroinflammation in SLE patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect