Activation of nitriles by silver(I) N-heterocyclic carbenes: An efficient on-water synthesis of primary amides

Autor:	Narasimha Swamy Thirukovela, Ramesh Balaboina, Chandra Sekhar Vasam, Ravindhar Vadde, Shravankumar Kankala
Rok vydání:	2019
Předmět:	Reaction conditions Primary (chemistry) 010405 organic chemistry Chemistry Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry 0104 chemical sciences Catalysis chemistry.chemical_compound Drug Discovery Organic chemistry Carbene
Zdroj:	Tetrahedron. 75:2637-2641
ISSN:	0040-4020
DOI:	10.1016/j.tet.2019.03.017
Popis:	A first example of silver(I) N-heterocyclic carbene (Ag(I)-NHC) catalyzed on-water synthesis of primary amides by hydration of nitriles under mild reaction conditions is described. This organometallic catalytic system has excellent tolerance for various homo-aromatic, hetero-aromatic and aliphatic nitriles to afford primary amides in good yields in neat water.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::39e9fda10f170672c913f28d289c8177 https://doi.org/10.1016/j.tet.2019.03.017 Zobrazit plný text záznamu Full Text from ScienceDirect