| Popis: |
A series of experiments into plasma concentrations of d-tubocurarine in the dog is described. It was found that the higher the blood pH at which distribution of the drug was taking place the lower were the plasma concentrations, and vice versa. The plasma concentrations diminished when the blood pH was raised during the distribution of the drug but it was not found possible to demonstrate an increase in plasma concentrations when the blood pH was lowered. This relationship between plasma concentrations and pH was apparently not mediated by a renal mechanism. The significance of these findings is discussed. |
