Lifespan Perspective on Congenital Heart Disease Research
| Autor: | Michael Α. Gatzoulis, Alexander R. Opotowsky, Kathy J. Jenkins, Gerhard-Paul Diller, Animesh Tandon, Alexandra Arvanitaki, Seema Mital, Ariane Marelli, Yue Li, Alexander Kempny, Andrew N. Redington, Paul Khairy, Philip Moons |
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| Rok vydání: | 2021 |
| Předmět: |
Gerontology
education.field_of_study Operationalization Heart disease business.industry Perspective (graphical) Population 030204 cardiovascular system & hematology Phenome Precision medicine medicine.disease 03 medical and health sciences 0302 clinical medicine Paradigm shift Medicine Observational study cardiovascular diseases 030212 general & internal medicine Cardiology and Cardiovascular Medicine business education |
| Zdroj: | Journal of the American College of Cardiology. 77:2219-2235 |
| ISSN: | 0735-1097 |
| DOI: | 10.1016/j.jacc.2021.03.012 |
| Popis: | More than 90% of patients with congenital heart disease (CHD) are nowadays surviving to adulthood and adults account for over two-thirds of the contemporary CHD population in Western countries. Although outcomes are improved, surgery does not cure CHD. Decades of longitudinal observational data are currently motivating a paradigm shift toward a lifespan perspective and proactive approach to CHD care. The aim of this review is to operationalize these emerging concepts by presenting new constructs in CHD research. These concepts include long-term trajectories and a life course epidemiology framework. Focusing on a precision health, we propose to integrate our current knowledge on the genome, phenome, and environome across the CHD lifespan. We also summarize the potential of technology, especially machine learning, to facilitate longitudinal research by embracing big data and multicenter lifelong data collection. |
| Databáze: | OpenAIRE |
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