HLA-DRB1 ALLELE DISTRIBUTION IN HEALTHY INDIVIDUALS CLASSIFIED BASED ON MIZAJ (TEMPERAMENT) OF UNANI SYSTEM OF MEDICINE

Autor:	GHAZALA MULLA, TEJAS SHAH, KALPANA JOSHI, JALIS AHMED, FARHAN QURESHI
Rok vydání:	2022
Předmět:	Pharmacology Pharmaceutical Science Pharmacology (medical)
Zdroj:	Asian Journal of Pharmaceutical and Clinical Research. :75-83
ISSN:	2455-3891 0974-2441
DOI:	10.22159/ajpcr.2022.v15i8.44832
Popis:	Objective: Assessment of Mizaj of 500 healthy individuals between the age group of 25and 40 years of the age group of either gender was carried out by validated Unani questionnaire and Sheldon’s somatotype. The present study was designed to investigate if the frequency of HLA-DRB1 alleles in the healthy adult population has any association with four Mizaj. Methods: Mizaj of the healthy individuals (n=500) was assessed by a validated Unani questionnaire based on 10 parameters related to phenotypic and psychological entities known as Ajnas-e-Ashra. Mizaj of the same subjects was further assessed by Sheldon’s somatoplot. Polymerase chain reaction-sequence-specific typing method was used for human leukocyte antigen (HLA) genotyping of 180 healthy volunteers. Conclusion: An expected correlation between HLA-DRB1 alleles and Mizaj types is observed. Five single-nucleotide polymorphisms (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::39dad57ed3f25ae2476bcb3341d40d85 https://doi.org/10.22159/ajpcr.2022.v15i8.44832 Zobrazit plný text záznamu