Possible Structural Implications of 20 Mutations in the Protein C Protease Domain
| Autor: | John H. Griffin, Judith S. Greengard, Cindy L. Fisher |
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| Rok vydání: | 1994 |
| Předmět: | |
| Zdroj: | Thrombosis and Haemostasis. 72:869-873 |
| ISSN: | 2567-689X 0340-6245 |
| DOI: | 10.1055/s-0038-1648976 |
| Popis: | SummaryAnalysis of naturally occurring protein mutations yields valuable insights into functionally important sequences. Characterizing mutations responsible for protein C deficiency at the molecular level has been the subject of intensive investigation. In a previous study, a three-dimensional model of the serine protease domain of protein C was used to analyze the set of protease domain mutations previously available. The mutations were largely found to fall into a limited number of categories. A recently updated protein C mutation data base has provided a number of new mutations which have been analyzed for structural predictions. |
| Databáze: | OpenAIRE |
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