Determination of Clopidogrel by Chromatography
| Autor: | Radka Opatrilova, Vladimír Šrámek, Lenka Vocilková |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Chromatography
Chemistry Biophysics Pharmaceutical Science Pharmacology Clopidogrel Biochemistry High-performance liquid chromatography Human plasma medicine Molecular Medicine Platelet aggregation inhibitor In patient cardiovascular diseases Hplc method circulatory and respiratory physiology medicine.drug |
| Zdroj: | Current Pharmaceutical Analysis. 5:424-431 |
| ISSN: | 1573-4129 |
| DOI: | 10.2174/157341209789649131 |
| Popis: | Clopidogrel, being a potent platelet aggregation inhibitor, is used widely around the world to reduce cardiovas- cular risks in patients with stroke, myocardial infarction, and atherosclerosis. The aim of this review firstly focuses on a comprehensive update of chromatography determination of clopidogrel and its metabolites as well as in human plasma, Wistar rat plasma, and in pharmaceutical preparations. It has been described using TLC, HPLC/MS, RP-HPLC, and GC/MS methods. Secondly to localize the chromatography conditions for separation and quantification, this review pro- vides detailed information on separation conditions for clopidogrel and its metabolites. A new HPLC method adjusted to our laboratory conditions was developed for the evaluation of assay and purity of clopidogrel in film-coated tablets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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