| Autor: |
Dilhumare Ablikim, Xiaoqing Zeng, Chunli Xu, Mengxiao Zhao, Xuecheng Yang, Xuemei Feng, Jia Liu |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Journal of Clinical Medicine. 12:2000 |
| ISSN: |
2077-0383 |
| DOI: |
10.3390/jcm12052000 |
| Popis: |
Chronic hepatitis B virus (HBV) infection continues to be a global public health burden. B cells play a pivotal role in mediating HBV clearance and can participate in the development of anti-HBV adaptive immune responses through multiple mechanisms, such as antibody production, antigen presentation, and immune regulation. However, B cell phenotypic and functional disorders are frequently observed during chronic HBV infection, suggesting the necessity of targeting the disordered anti-HBV B cell responses to design and test new immune therapeutic strategies for the treatment of chronic HBV infection. In this review, we provide a comprehensive summary of the multiple roles of B cells in mediating HBV clearance and pathogenesis as well as the latest developments in understanding the immune dysfunction of B cells in chronic HBV infection. Additionally, we discuss novel immune therapeutic strategies that aim to enhance anti-HBV B cell responses for curing chronic HBV infection. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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