Analogs of arginine vasopressin modified in position 3 with (R)-α- hydroxymethylphenylalanine

Autor:	Olma A, Jirina Slaninova, Lempicka E, Bernard Lammek
Rok vydání:	1999
Předmět:	Arginine vasopressin receptor 1B endocrine system medicine.medical_specialty Vasopressin Arginine Chemistry Alpha (ethology) Uterotonic Antidiuretic Activity Biochemistry Endocrinology Internal medicine medicine hormones hormone substitutes and hormone antagonists Antidiuretic
Zdroj:	The Journal of Peptide Research. 53:554-559
ISSN:	1397-002X
DOI:	10.1034/j.1399-3011.1999.00064.x
Popis:	This study describes the synthesis and some pharmacological properties of three new analogs of arginine vasopressin (AVP) substituted in position 3 with (R)-alpha-hydroxymethylphenylalanine ([R]-HmPhe). All new peptides were tested for vasopressor and antidiuretic as well as uterotonic activity. None of the 3 analogs showed any pressor activity and their uterotonic activity was negligible. Only analog [Mpa1,(R)-HmPhe3]AVP exhibited significant antidiuretic activity.
Databáze:	OpenAIRE
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