Radiation stability of resveratrol in immobilization on poly vinyl pyrrolidone hydrogel dressing for dermatological use
| Autor: | Patrick Jack Spencer, Carolina S. Moreno, Ademar B. Lugão, Roberta G. R. A. P. Momesso, Sizue Ota Rogero, Jose R. Rogero |
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| Rok vydání: | 2010 |
| Předmět: |
Radiation
Ethanol Antioxidant Polyvinylpyrrolidone medicine.medical_treatment technology industry and agriculture food and beverages macromolecular substances Resveratrol chemistry.chemical_compound Hydrolysis chemistry Polyphenol Self-healing hydrogels medicine Organic chemistry Swelling medicine.symptom medicine.drug Nuclear chemistry |
| Zdroj: | Radiation Physics and Chemistry. 79:283-285 |
| ISSN: | 0969-806X |
| Popis: | The polyphenol trans-resveratrol is a natural phytoalexin, which is found in red wine and in a wide variety of plant species. Resveratrol displays a wide array of biological activities, such as modulation of lipid metabolism, anti-inflammatory and antioxidant activities. This active compound immobilized in polyvinylpyrrolidone (PVP) hydrogel could be very interesting for topical administration, as a dressing form for dermatological use. However, PVP hydrogel obtained by radiation-induced crosslinking can cause undesirable hydrolysis reactions in the active compound. The aim of this work was to verify the resveratrol stability after irradiation at 0.5 and 1 kGy in the presence of ethanol, methanol or tert -butyl alcohol. The integrity of these samples was compared to unirradiated resveratrol by HPLC. The PVP hydrogel matrix was characterized by gel fraction, swelling and in vitro biocompatibility test. The results of gel fraction and swelling degree were approximately 90% and 1600%, respectively. The cytotoxicity assay showed absence of toxicity for this formulation after crosslinking and sterilization, indicating that the PVP hydrogel formulation was appropriate for resveratrol immobilization to produce a dressing for dermatological use. |
| Databáze: | OpenAIRE |
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