A Novel Nitrone Cycloaddition/Rearrangement
| Autor: | Vassil St. Georgiev, Bruce H. Toder, G. B. Mullen |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
chemistry.chemical_classification
Stereochemistry Organic Chemistry Biochemistry Aldehyde Toluene Oxaziridine Medicinal chemistry Catalysis Cycloaddition Nitrone Inorganic Chemistry chemistry.chemical_compound chemistry Fragmentation (mass spectrometry) Drug Discovery Physical and Theoretical Chemistry Aliphatic compound Tetrahydrofuran |
| Zdroj: | Helvetica Chimica Acta. 73:169-173 |
| ISSN: | 1522-2675 0018-019X |
| DOI: | 10.1002/hlca.19900730119 |
| Popis: | Adamantanone-derived nitrone 4 and some other keto-nitrones, when reacted with aromatic and aliphatic aldehydes in refluxing toluene or tetrahydrofuran, formed the corresponding aldonitrones (Z)-10, the latter arising from the fragmentation of an initially formed 1,4,2-dioxazolidine 6 to adamantan-2-one and an oxaziridine intermediate 11, which then rearranges to (Z)-10. |
| Databáze: | OpenAIRE |
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