Iron-Catalyzed C–H Sulfonylmethylation of Indoles in Water–PEG400

Autor:	Xinju Zhu, Tian-Wei Cui, Xin-Qi Hao, Ke-Xin Yan, Shuai Lu, Mao-Ping Song, Yu-Shen Zhu
Rok vydání:	2019
Předmět:	chemistry.chemical_compound chemistry 010405 organic chemistry Isocyanide Iron catalyzed Organic Chemistry Regioselectivity 010402 general chemistry 01 natural sciences Combinatorial chemistry Environmentally friendly 0104 chemical sciences
Zdroj:	Synlett. 30:1924-1928
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0039-1690675
Popis:	An iron-catalyzed C–H sulfonylmethylation of indoles in water–PEG400 has been developed using p-toluenesulfonylmethyl isocyanide. This protocol enables direct regioselective construction of Csp2–Csp3 bond at the C3 position of indoles with a broad range of substrate compatibility in moderate to good yields, which is cost-effective and environmentally friendly.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::39ba16148f323708aa2efb695eebc652 https://doi.org/10.1055/s-0039-1690675 Zobrazit plný text záznamu