| Popis: |
It is widely known that sciatic nerve injury (SNI) can negatively affect the biomechanical characteristicsof the musculoskeletal system. However, there were no studies that evaluated and compared denervated side withanother side limb at the same time. In this study, sixteen male 12-week-old mice were allocated into two groups:HEMI (Right Sciatic nerve denervated) and CON (Control). Both limbs were scanned using micro-CT at 0 week and4 weeks. There were significant differences in relative variation (RV) of BMD and all structural parameters comparedCON and HEMI in right tibia (p < 0.05). Tb.Th and Tb.Sp distributions were differed CON with HEMI in right tibia.In left tibia, there were significant differences in RV of BMD (p < 0.05) and Tb.Sp distribution. These result meansthat SNI can induce bone loss in the both side tibiae. However, there was a different profile of bone loss betweenleft and right tibiae.Key words: Hemiplegia, Sciatic nerve injury, Trabecular bone, Bone loss |
