Betaine treatment decreased serum glucose and lipid levels, hepatic and renal oxidative stress in streptozotocin-induced diabetic rats
| Autor: | Müjdat Uysal, Mehmet Sar, Betül Evran, Semra Doğru-Abbasoğlu, Buse Uğuralp, Abdurrahman Fatih Aydin |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Kidney medicine.medical_specialty Chemistry Biochemistry (medical) Clinical Biochemistry medicine.disease medicine.disease_cause Streptozotocin Biochemistry 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology medicine.anatomical_structure Endocrinology Betaine Serum glucose Diabetes mellitus Internal medicine medicine Molecular Biology Oxidative stress medicine.drug |
| Zdroj: | Turkish Journal of Biochemistry. 43:343-351 |
| ISSN: | 1303-829X 0250-4685 |
| DOI: | 10.1515/tjb-2016-0183 |
| Popis: | Objective The present study was aimed to investigate the effects of betaine (BET) on streptozotocin (STZ)-induced diabetes mellitus (DM) in rats. Additionally, the efficiency of BET was compared with metformin (MET), a standard oral antidiabetic drug. Methods STZ (55 mg/kg body weight; i.p.) was injected to male Wistar rats. Rats with DM were treated with BET (1 g/kg body weight/day;) or MET (500 mg/kg body weight/day;) for 4 weeks. Blood glycated hemoglobin (HbA1c), serum glucose, lipids, hepatic and renal function tests and urinary protein levels were examined. Reactive oxygen species (ROS) formation, malondialdehyde (MDA), glutathione (GSH) levels, and ferric reducing antioxidant power (FRAP) were also determined in liver and kidney. Results Glucose, HbA1c, and serum lipids increased and liver and kidney function tests were impaired in diabetic rats. Hepatic and renal ROS formation and MDA levels were elevated, hepatic, but not renal GSH and FRAP levels were decreased. BET decreased blood HbA1c, serum glucose and lipid levels and urine protein levels. BET diminished hepatic and renal prooxidant status. Conclusion Our results indicate that BET may be effective in decreasing STZ-induced high levels of blood HbA1c, and serum glucose and lipid levels and prooxidant status in liver and kidney tissues. |
| Databáze: | OpenAIRE |
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