Continuous enantiomer separation of the volatile inhalation anesthetic enflurane with a gas chromatographic simulated moving bed unit
| Autor: | Markus Juza, Orazio Di Giovanni, Giovanni Biressi, Massimo Morbidelli, Volker Schurig, Marco Mazzotti |
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| Rok vydání: | 1998 |
| Předmět: |
chemistry.chemical_classification
Chromatography Cyclodextrin Chemistry Organic Chemistry Analytical chemistry General Medicine Biochemistry Chiral resolution Analytical Chemistry Matrix (chemical analysis) chemistry.chemical_compound Adsorption Gas chromatography Enantiomer Simulated moving bed Enantiomeric excess |
| Zdroj: | Journal of Chromatography A. 813:333-347 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/s0021-9673(98)00322-7 |
| Popis: | The separation of the enantiomers of the racemic inhalation anesthetic enflurane was achieved by continuous gas phase simulated moving bed chromatography (GC–SMB). The productivity of the unit and the enantiomeric excess of the obtained streams were somehow low mainly because of the high operating temperature, i.e., T =50°C. As chiral stationary phase, an unpurified cyclodextrin derivative, consisting of various isomers and homologues and dissolved in an apolar polysiloxane matrix, was used. The competitive adsorption isotherms of ( R )-(−)-enflurane and ( S )-(+)-enflurane were determined by gas chromatographic measurements at increasing values of the pulse concentration in the range from linear to overload conditions. It has been shown that the adsorption behavior of the two enantiomers can be explained by considering enantioselective and non-enantioselective sites on the stationary phase. These results demonstrate the feasibility of the chiral resolution of enflurane by GC–SMB. |
| Databáze: | OpenAIRE |
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