SIGNIFICANT LINKAGE DISEQUILIBRIUM AND HIGH GENETIC DIVERSITY IN A POPULATION OF PLASMODIUM FALCIPARUM FROM AN AREA (REPUBLIC OF THE CONGO) HIGHLY ENDEMIC FOR MALARIA

Autor:	S. Cestier, Yannis Michalakis, Marie Claude Leclerc, Michel Tibayrenc, B. Oury, Patrick Durand, François Renaud
Rok vydání:	2003
Předmět:	Genetics Linkage disequilibrium education.field_of_study Genetic diversity Wahlund effect Genetic heterogeneity Population Selfing Biology Infectious Diseases Evolutionary biology Virology Genetic variation Microsatellite Parasitology education
Zdroj:	The American Journal of Tropical Medicine and Hygiene. 68:345-349
ISSN:	1476-1645 0002-9637
DOI:	10.4269/ajtmh.2003.68.345
Popis:	A study based on 28 microsatellite loci was performed on 32 isolates of Plasmodium falciparum from Pointe Noire (Republic of the Congo) and compared with a cosmopolitan sample of 21 isolates collected from different countries in Africa, Latin America, and Asia. The Pointe Noire population exhibited very high genetic diversity (A = 7.8 ± 2.6, He = 0.79 ± 0.11). Significant linkage disequilibria were observed in 28 of 378 pairs of microsatellite loci. This result could be explained by two non-exclusive hypotheses: 1) uniparental propagation (i.e., selfing), leading to non-panmictic associations, and/or 2) a Wahlund effect (i.e., spatial population genetic heterogeneity). These observations are in agreement with data previously obtained from isozyme loci of the same isolates, but contrast with other population genetic analyses conducted in other hyperendemic zones.
Databáze:	OpenAIRE
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