Phenotypes of myocardial blood perfusion related to the genetic variations of metalloproteinases 3 (MMP3) and 9 (MMP9)
| Autor: | Alice Faria, Durval C. Costa, Claudia Escórcio, Begoña Criado, Aníbal Albuquerque |
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| Rok vydání: | 2013 |
| Předmět: |
MMP3
medicine.medical_specialty Pathology medicine.diagnostic_test business.industry Biomedical Engineering Computational Mechanics Single-nucleotide polymorphism medicine.disease Computer Science Applications body regions Myocardial perfusion imaging medicine.anatomical_structure Ventricle Internal medicine medicine Cardiology Radiology Nuclear Medicine and imaging Myocardial infarction Allele business Perfusion Coronary atherosclerosis |
| Zdroj: | Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization. 1:119-129 |
| ISSN: | 2168-1171 2168-1163 |
| Popis: | The myocardial perfusion is modified more frequently by coronary atherosclerosis, which can lead to cardiac dysfunction. The allelic variants can induce different phenotypes of left ventricle remodelling. The factors for expression of phenotypes of myocardial blood perfusion are not completely understood. The purpose of this study was to evaluate the influence of single nucleotide polymorphisms of metalloproteinase 3 (MMP3; rs3025058) and metalloproteinase 9 (MMP9; rs3918242) genes in the myocardial blood perfusion, and to determine the allelic variants that influence the susceptibility of myocardial perfusion abnormalities. Two hundred and five patients underwent myocardial perfusion imaging (MPI) with 99mTc-tetrofosmin in which was carried out for genotyping of MMP3 and MMP9 promoter gene polymorphism. Negative MPI to myocardial ischaemia was defined by absent of myocardial perfusion defects (MPD) and positive MPI to myocardial ischaemia was defined by presence of one or more reversible and/or irreversi... |
| Databáze: | OpenAIRE |
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