Induction of DNA — Damage after Rats Exposure to Crocidolite Asbestos Fibers

Autor:	W. Marek, Xaver Baur, Boleslaw Marczynski, T. Kerenyi
Rok vydání:	1994
Předmět:	Lung DNA damage Chemistry Phagocytosis medicine.disease_cause Molecular biology In vitro Asbestos chemistry.chemical_compound medicine.anatomical_structure In vivo medicine DNA Crocidolite Asbestos
Zdroj:	Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres ISBN: 9783642790430
DOI:	10.1007/978-3-642-79041-6_21
Popis:	Several experiments suggest that reactive oxygen metabolites generated after asbestos phagocytosis cause DNA damage. According to recent findings, crocidolite is able to induce DNA strand breaks in vitro. The aim of this study was to find out whether crocidolite asbestos fibers induce in vivo double-strand breaks in the DNA of white blood cells and in the nuclei of lung and liver. Male Wistar rats received a single tracheostoma instillation of 2.5 mg UICC crocidolite asbestos into the right lung. The same dose was injected intraperitoneally. The animals were sacrificed 4 and 13 months after instillation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::397ac35803c6bdb4c98178076d383237 https://doi.org/10.1007/978-3-642-79041-6_21 Zobrazit plný text záznamu