The effects of iloprost infusion on microcirculation is independent of nitric oxide metabolites and endothelin-1 in chronic peripheral ischaemia
| Autor: | D. Gritti, Iolanda Mazzucchelli, I Buggia, C. Cusa, Gianluca Fossati, Luigi Bucci, Stefano Ghio, Monia Vezzoli, Antonino Mazzone, M. B Regazzi |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
Endothelium business.industry Vascular disease Clinical Biochemistry Ischemia Prostacyclin Vasodilation General Medicine medicine.disease Biochemistry Endothelin 1 Microcirculation Endocrinology medicine.anatomical_structure Internal medicine medicine Cardiology business medicine.drug Iloprost |
| Zdroj: | European Journal of Clinical Investigation. 29:1-5 |
| ISSN: | 0014-2972 |
| Popis: | Background Endothelial vascular tone modulators are thought to be involved in aetiopathogenesis of systemic sclerosis (SS) and of peripheral artery occlusive disease (PAOD). Iloprost, a prostacyclin (PGI2) analogue, induces clinical benefit in patients suffering from peripheral ischaemia. This study was performed to investigate the effect of this drug on endothelial function in vivo to elucidate the role of vascular tone modulators. Methods Fourteen PAOD and 15 SS patients were treated for 24 and 10 days respectively. On the first day, before and after therapy, nitric oxide metabolites (NO2−/NO3−) and endothelin-1 (ET-1) plasma concentrations were detected; moreover, the endothelium-dependent vasodilatation in response to artificial ischaemia was evaluated by means of an echo-Doppler device. Results The echo-Doppler evaluation showed that the percentage of arterial reactive dilatation was not modified by placebo or by iloprost, and that the increase in blood velocity flow lasted for a significant longer time after drug infusion (226.79 ± 17.49 vs. 310.71 ± 36.32 s; P > 0.04). NO2−/NO3− and ET-1 plasma concentration were higher in patients than in control subjects (P |
| Databáze: | OpenAIRE |
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