| Autor: |
Hyeong Soo Nam, Yeon Hoon Kim, Un Gyo Kang, Min Woo Lee, Jae Won Ahn, Hongki Yoo, Jeongmoo Han, Jin Won Kim, Hyun Jung Kim, Dong Oh Kang, Joon Woo Song, Kyeongsoon Park, Ryeong Hyun Kim |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Diagnostic and Therapeutic Applications of Light in Cardiology 2021. |
| Popis: |
Photoactivation is a promising theranostic tool to image and stabilize the atherosclerotic plaque by apoptosis induction in macrophages or other vascular cells; however, lack of effective drugs and mechanistic understanding hinder its clinical application for cardiovascular disease. Here, we developed the macrophage targeted photosensitizer delivery strategy and demonstrated that imaging assisted light activation reduced inflammation and burden of atherosclerotic plaques. Mechanistically, targeted photoactivation induced autophagy and increased MerTK expression in carotid atheroma as early as 1 day, and had 2-fold increase in macrophage-associated apoptotic cells, indicating efferocytosis enhancement. This multifunctional photoactivatable theranostic strategy could confer a promising tool for high-risk plaques. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
