Chemical composition, larvicidal and cytotoxic activities of the leaf essential oil of Bauhinia cheilantha (Bong.) Steud
| Autor: | Albina Silva, Nirla Rodrigues Romero, G. M. P. Santiago, H.V. Santos, Aurelio de Oliveira Monteiro, Gardênia Carmem Gadelha Militão, Péricles Barreto Alves, Telma L. G. Lemos, H.C. da Silva, S.M. de Souza |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
biology Traditional medicine Chemistry Plant Science Aedes aegypti biology.organism_classification 01 natural sciences 0104 chemical sciences law.invention 010404 medicinal & biomolecular chemistry Bauhinia cheilantha Caryophyllene oxide law Ic50 values Cytotoxic T cell Instar Chemical composition Essential oil 010606 plant biology & botany |
| Zdroj: | South African Journal of Botany. 131:369-373 |
| ISSN: | 0254-6299 |
| DOI: | 10.1016/j.sajb.2020.03.011 |
| Popis: | The essential oil obtained by hydrodistillation from fresh leaves of Bauhinia cheilantha was analysed by GC-FID and GC-MS. The chemical composition of the essential oil was dominated by sesquiterpenes (78.59%). The major components were identified as (E)-caryophyllene (21.65%), α-pinene (11.75%), spathulenol (4.84%) and caryophyllene oxide (4.62%). The larvicidal potential of the oil was evaluated against instar III larvae of Aedes aegypti, and showed LC50 value of 40.84 ± 0.87 μg/mL. The in vitro cytotoxic activity of the essential oil has been evaluated on pro-myelocytic leukemia (HL-60), lung carcinoma (NCI-H292), breast adenocarcinoma (MCF-7), and cervical adenocarcinoma (HEP-2) human tumor cell lines, and this analysis showed that the essential oil was more active against pro-myelocytic leukemia (HL-60) and breast adenocarcinoma (MCF-7) cell lines with IC50 values of 8.6 and 18.3 μg/mL, respectively. This is the first report on chemical composition, larvicidal and cytotoxic activities of this essential oil. |
| Databáze: | OpenAIRE |
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