Isolation of new secondary metabolites from the liana Landolphia lucida K. Schum. (Apocynaceae)
| Autor: | Nuzhat Shehla, Dieudonné Emmanuel Pegnyemb, Muhammad Iqbal Choudhary, Guy Roland Ebede, Joséphine Ngo Mbing, Joseph Thierry Ndongo, Atta-ur Rahman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Circular dichroism food.ingredient Apocynaceae biology 010405 organic chemistry Chemistry Stereochemistry Landolphia Ether Plant Science biology.organism_classification 01 natural sciences Biochemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound food Triterpene Methandriol Dipropionate Antibacterial activity Agronomy and Crop Science Two-dimensional nuclear magnetic resonance spectroscopy Biotechnology |
| Zdroj: | Phytochemistry Letters. 41:27-33 |
| ISSN: | 1874-3900 |
| Popis: | A new pentacyclic triterpene 3-O-β-(E)-(4-O-acetylferuloyl)-lupeol (1) possessing an unusual (E)-acetylferuloyl moiety at C-3 and a new bicoumarin 7,7′-dimethoxy-6,6′-dicoumarinyl ether (2) were isolated from the liana Landolphia lucida K. Schum, along with fourteen previously known compounds 3-16, where methandriol dipropionate (3) and 2,3-bis-(4-hydroxy-3-methoxy-benzyl)-dimethyl- succinate (5) were obtained for the first time from natural sources. The structures of the new compounds were established on the basis of extensive 1D and 2D NMR spectroscopy, and HRMS data analyses. The absolute configuration of 1 was determined by circular dichroism (CD) spectroscopy. Furthermore, compounds 1 and 2 had exhibited a significant antibacterial activity against Escherichia coli (ATCC 25922) with MIC values of 2.3 μM and 4.6 μM, respectively; while compounds 4 and 5 showed antiglycation and α-glucosidase inhibitory activities. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect