| Popis: |
We are studying immune response to natural and synthetic antigens as related to viability and disease and are attempting to determine the extent to which the major histocompatibility complex (the B blood group system) is involved. We are using a noninbred line, SI, segregating for 3 B alleles and 7 inbred lines with inbreeding coefficients ranging from 60–97%. This gives us the opportunity to compare the experimental efficiency of inbreds and noninbreds for studies of immune response. A unique feature of our approach concerns the B1B1 genotype. In particular, B1B1 chickens show consistently high adult mortality, 4- or 5-fold higher than controls, and they are highly susceptible to Marek’s disease virus. Also, they have proved to be low responders to Salmonella pullorum bacterin, human serum albumin, GAT10, and (T, G)-A—L. We think that there is some broad immunodeficiency associated with BIBI but as yet we have not discovered it. |
