The expansive library of jadomycins
| Autor: | Jeanna M. MacLeod, David L. Jakeman, Stephanie M. Forget |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Streptomyces venezuelae
biology 010405 organic chemistry Chemistry Organic Chemistry General Chemistry Computational biology Secondary metabolite 010402 general chemistry biology.organism_classification 01 natural sciences Catalysis 0104 chemical sciences Mini review Combinatorial biosynthesis Gene cluster medicine Identification (biology) Expansive medicine.drug |
| Zdroj: | Canadian Journal of Chemistry. 96:495-501 |
| ISSN: | 1480-3291 0008-4042 |
| Popis: | The jadomycin family of natural products was discovered from Streptomyces venezuelae ISP5230 in the 1990s. Subsequent identification of the biosynthetic gene cluster along with synthetic efforts established that incorporation of an amino acid into the polyaromatic angucycline core occurs non-enzymatically. Over two decades, the precursor-directed biosynthetic potential of the jadomycins has been heavily exploited, generating a library exceeding 70 compounds. This review compiles the jadomycins that have been isolated and characterized to date; these include jadomycins incorporating proteinogenic and non-proteinogenic amino acids, semi-synthetic derivatives, biosynthetic shunt products, compounds isolated in structural gene deletion studies, and deoxysugar sugar variant jadomycins produced by deletion or heterologous expression of sugar biosynthetic genes. |
| Databáze: | OpenAIRE |
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