CLINICOPATHOLOGICAL CHARACTERIZATION OF 122 CASES OF ORAL LEUKOPLAKIA

Autor: Larissa Abbehusen Couto, Lorena Vieira Sacramento, Águida Cristina Gomes Henriques Leitão, Simone Cristina Leal Tosta Dos Santos, Vildeman Rodrigues de Almeida Júnior, Ianna Josefa Valeska De Aniz Castro
Rok vydání: 2020
Předmět:
Zdroj: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 130:e271
ISSN: 2212-4403
2002-2018
DOI: 10.1016/j.oooo.2020.04.735
Popis: Oral leukoplakia (OL) is the most common oral potentially malignant disorder, which manifests as white plaques with the possibility of malignant transformation. Microscopically, OL may exhibit epithelial dysplasia, as well as have carcinoma characteristics. These variations reflect on the risk of transformation and prognosis for the patient. Objective: This study aimed to describe the clinical profile of OL in a series of 122 cases diagnosed in the period from 2002-2018. Study Design: Information regarding age, sex, lesion size and location, type of biopsy, and histopathological diagnosis were analyzed. Results: The mean age of the patients was 55 years, with no predilection for sex. The lesions had a mean size of 1.6 cm. The jugal mucosa was the most affected location (21.3%), followed by the alveolar ridge (20.5%). Incisional biopsy was performed in 46.7% of the cases. The most frequent histopathological diagnoses were hyperkeratosis (68%), low risk epithelial dysplasia (20.5%), and high risk epithelial dysplasia (HRED; 4.9%). Squamous cell carcinoma (SCC) showed the larger sizes (2.5 cm), followed by HRED (2.2 cm). Conclusion: Our study of the clinicopathological profile of OL suggests that early diagnosis and appropriate intervention of OLs can prevent the progression of these alterations to SCC.
Databáze: OpenAIRE
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