Serotonin Vascular Reactivity and Other Clinical Pharmacological Investigations in Two Intestinal Carcinoid Patients1

Autor:	Federigo Sicuteri, M. Fanciullacci, C. Curradi, G. Franchi, A. Lagi
Rok vydání:	2015
Předmět:	Amine oxidase medicine.medical_specialty Intestinal carcinoid business.industry medicine.disease Isozyme Vascular reactivity Endocrinology High plasma Internal medicine medicine Serotonin Platelet monoamine oxidase business Carcinoid syndrome
DOI:	10.1159/000399338
Popis:	In two patients with carcinoid syndrome, a reduced venoreactivity to serotonin (5-HT) was found by means of the venoconstriction test. Parachlorophenylalanine (PCPA) treatment increased 5-HT venoreactivity. A normal noradrenaline venoreactivity was detected before and during PCPA administration. The altered platelet monoamine oxidase (MAO) activity corrected by PCPA treatment. The abnormal 5-HT turnover may alter the synthesis of MAO and provoke the production of isoenzymes. Low plasma amine oxidase and high plasma histaminase activity were found in 1 of these 2 patients. A low level of plasma prekallikrein in the two patients remained unchanged during PCPA administration.
Databáze:	OpenAIRE
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