Tau positron emission tomography using [18F]THK5351 and cerebral glucose hypometabolism in Alzheimer's disease
| Autor: | Duk L. Na, Victor L. Villemagne, Seongho Seo, Hyon Lee, Young Noh, Yeong Bae Lee, Joon Kyung Seong, Kazuhiko Yanai, Nobuyuki Okamura, Tatsuo Ido, Jaelim Cho, Kee Hyung Park, Shozo Furumoto, Sung Ho Woo, Hye Jin Jeong, Kyoung Min Lee, Hye Jin Kang, Sang-Yoon Lee, Dong Hoon Shin, Byeong Kil Yeon, Jae Myeong Kang |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging medicine.medical_specialty 03 medical and health sciences 0302 clinical medicine Internal medicine mental disorders Severity of illness medicine Dementia Fluorodeoxyglucose medicine.diagnostic_test business.industry General Neuroscience Neuropsychology Magnetic resonance imaging Neuropsychological test medicine.disease 030104 developmental biology Positron emission tomography Cardiology Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Psychology Nuclear medicine business 030217 neurology & neurosurgery Developmental Biology medicine.drug |
| Zdroj: | Neurobiology of Aging. 59:210-219 |
| ISSN: | 0197-4580 |
| DOI: | 10.1016/j.neurobiolaging.2017.08.008 |
| Popis: | This study aims to evaluate the clinical validity of [18F]THK5351 positron emission tomography (PET) for the assessment of disease progression and symptoms in Alzheimer's disease (AD). Fifty-one patients with AD dementia, 30 patients with amnestic mild cognitive impairment (aMCI), and 43 controls with normal cognition (NC) were included. All subjects underwent [18F]THK5351 PET, 3.0-T magnetic resonance imaging, and detailed neuropsychological tests. Regions of interest and voxel-based statistical analyses were performed. In patients with AD dementia, [18F]THK5351 retention was greater in most association cortices as well as the limbic area compared to NC or aMCI participants. Patients with aMCI also showed higher THK5351 retention in those areas compared to NC. [18F]THK5351 retention significantly correlated with neuropsychological test results. Negative correlations between [18F]THK5351 and [18F] fluorodeoxyglucose were observed in AD dementia and aMCI groups. Mirror images of [18F]THK5351 retention and glucose hypometabolism in [18F] fluorodeoxyglucose were noticeable in the focal variants of AD. [18F]THK5351 PET reflects disease severity and symptoms in AD. Our results suggest [18F]THK5351 is reflective of tau-related AD pathology. |
| Databáze: | OpenAIRE |
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