An expeditious protocol for synthesis of Baylis–Hillman derived piperazine derivatives and evaluation of their AChE inhibition

Autor:	Pamanji Rajesh, Vaidya Jayathirtha Rao, Nanubolu Jagadeesh, Gangasani Jagadeesh Kumar, Parvathaneni Sai Prathima, Janapala Venkateswara Rao, Raktani Bikshapathi, B. Yashwanth
Rok vydání:	2017
Předmět:	Reaction conditions 010405 organic chemistry Chemistry Substrate (chemistry) Biological activity General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis Piperazine chemistry.chemical_compound Derivative (finance) Organic chemistry
Zdroj:	Research on Chemical Intermediates. 44:553-565
ISSN:	1568-5675 0922-6168
Popis:	The highly efficient and eco-economical “on water” method has been developed for the rapid construction of highly functionalized Baylis–Hillman derived piperazine derivatives (n = 34) in excellent yields under mild, catalyst-free reaction conditions. All the synthesized compounds were further screened for in vitro ACE inhibitor activity. This process has a broad substrate scope, is operationally simple, generally requires no chromatographic purification, is scalable and is significantly greener than current alternatives. The molecular and crystal structures of new piperazine derivative 3r have been investigated. The synthesised compounds exhibit several structural features that make them promising candidates as biologically active compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::394de76fdc013b217e1dee2bad77b832 https://doi.org/10.1007/s11164-017-3119-9 Zobrazit plný text záznamu Full text from SpringerLink