Regularities of changes in microcirculatory flow through different parts of the heart in patients with acquired valvular disease before and after surgery

Autor: Voronova Ip, Vlasov IuA, Zhelezchikov Ve, Sergey Zheleznev, Alexander Karaskov, Okuneva Gn, Dukhnov Vv, Vladimir M Nazarov, Bulatetskaia Lm
Rok vydání: 2005
Předmět:
Zdroj: Human Physiology. 31:32-39
ISSN: 1608-3164
0362-1197
DOI: 10.1007/s10747-005-0005-4
Popis: Microcirculation in the subepicardium was studied in 30 patients with aortic acquired valvular disease (AVD) and 20 with mitral AVD with the use of an ALF-21 laser Doppler blood flowmeter (Transonic Systems). In total, 845 measurements were made. Subepimyocardial flow (EMF) was measured on the anterior surface of the right and left atria and on the anterior, posterior, and diaphragmatic surfaces of the left and right ventricles of the heart before and after surgery. A decrease in the hyperfunctioning of the chambers of the heart led to a redistribution of myocardial flow. Differences (ΔEMF) between EMF values observed before and after treatment were analyzed, and the coefficients for the linear equation ΔEMF = a + kEMFbs were computed by the least-squares method. It was found that blood flow decreased when it was enhanced before treatment and increased when it was weak initially. Thus, blood flow was balanced, approaching a value that did not change after treatment, and heterogeneity of coronary flow in the microcirculatory link decreased. Control mechanisms were assumed to change blood flow so that it acquires stability, which is needed to preserve and maintain normal energy parameters of the functioning myocardium.
Databáze: OpenAIRE
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