Is there a Life in the Cold without UCP1? Uncoupling Proteins and Thermoregulatory Thermogenesis

Autor:	Jan Nedergaard, Kerstin B. E. Ohlson, Barbara Cannon, Anders Jacobsson, Anita Matthias, Valeria Golozoubova
Rok vydání:	2000
Předmět:	medicine.medical_specialty Chemistry Thermogenin Endocrinology medicine.anatomical_structure Adrenergic stimulation Internal medicine Basal metabolic rate Brown adipose tissue medicine Cold acclimation Uncoupling protein Thermogenesis UCP3
Zdroj:	Life in the Cold ISBN: 9783642086823
DOI:	10.1007/978-3-662-04162-8_42
Popis:	The original uncoupling protein UCP1 (thermogenin) is only found in brown adipose tissue which is only found in mammals. UCP1 is supposed to be the molecular basis for nonshivering thermogenesis. This tenet can be tested in the UCP1-ablated mice now available. Basically the results from investigation of these mice are very clear: there is no other mammalian nonshivering thermogenesis than that emanating from adrenergic stimulation of brown adipose tissue. No other proteins, not even the closely related UCP2 and UCP3, can take over as thermogenic proteins, even in the absence of UCP1.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::393ee1ae102e61736ad7f54aef965ebf https://doi.org/10.1007/978-3-662-04162-8_42 Zobrazit plný text záznamu