Prefrontal BOLD Responses Coupled to Changing Emotional Faces in Adolescents with and without a History of Suicide Attempt

Autor: Lisa Pan, Mary L. Phillips, Jay C. Fournier, Anna Maria Segreti, David A. Brent, Henry W. Chase
Rok vydání: 2020
Předmět:
Zdroj: Journal of Medical Psychology. 22:45-54
ISSN: 2468-3892
2468-3884
DOI: 10.3233/jmp-180018
Popis: Background: Functional abnormalities in emotion processing neural circuitry in adolescents with a history of suicide attempt relative to depressed adolescents with no history of suicide and healthy controls have been identified, typically utilizing static face presentations. Objective: The objective of the present work was to characterize functional activations associated with emotional face processing in adolescents with and without a history of suicide attempt. Methods: 64 adolescents including 19 with a history of depression and suicide attempt (ATT), 22 with a history of depression but no suicide attempt (NAT) and 23 healthy controls (HC) performed an implicit emotional-faces task during functional neuroimaging, in which they identified a color label superimposed on neutral faces that dynamically morphed into one of four emotional faces (angry, fearful, sad, and happy). Results: HC showed greater Blood Oxygenation Level Dependent (BOLD) responses compared with ATT in the Right Dorsolateral Prefrontal Cortex (rDLPFC) to all emotional faces compared to shapes. A similar pattern of group differences was seen when both ATT and NAT groups were compared with HC. Across all participants, an association between child trauma and rDLPFC activation was seen, although this was not corrected for multiple comparisons. Conclusions: Together, the findings are consistent with prior observations of emotion-related alterations in neural function in suicide attempters. However, they also suggest that adequate control groups are necessary to dissociate specific correlates of suicide risk from depression or trauma severity, which may contribute to prefrontal alterations in emotion processing.
Databáze: OpenAIRE
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