The Synthesis of a 5HT2C Receptor Agonist

Autor:	Pingli Liu, James P. Sherbine, Patrick J. Sheeran, Stephen R. Anderson, Benjamin R. P. Stone, Jiang Zhu, Subodh Shrinivas Deshmukh, James J. Haley, Nicholas A. Magnus, Lindsay A. Hobson, William A. Nugent
Rok vydání:	2007
Předmět:	Indole test Agonist Stereochemistry Chemistry medicine.drug_class Organic Chemistry chemistry.chemical_compound Suzuki reaction Indoline medicine Molecule Physical and Theoretical Chemistry Enantiomer Receptor Salt formation
Zdroj:	Organic Process Research & Development. 11:985-995
ISSN:	1520-586X 1083-6160
Popis:	This report describes the large-scale synthesis of 1 that features a Fischer indole strategy to form an advanced intermediate followed by reduction to the indoline to construct the tetracyclic core of the molecule. Resolution using dibenzoyl-d-tartaric acid affords access to a single enantiomer, from which a Suzuki coupling builds in the biaryl functionality. Deprotection followed by salt formation furnishes the desired target molecule.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::393af969ac69807fc8425c2d159826f9 https://doi.org/10.1021/op700121y Zobrazit plný text záznamu