| Autor: |
Kwanghoon Chung, Iksoo Chang, Mookyung Cheon, Suhkmann Kim, Muyoung Heo |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Interdisciplinary Bio Central. 1:1-6 |
| ISSN: |
2005-8543 |
| DOI: |
10.4051/ibc.2009.2.0008 |
| Popis: |
It is a challenge to design a protein score function which stabilizes the native structures of many proteins simultaneously. The coarse-grained description of proteins to construct the pairwise-contact score function usually ignores the backbone directionality of protein structures. We propose a new two-body score function which stabilizes all native states of 1,006 proteins simultaneously. This two-body score function differs from the usual pairwise-contact functions in that it considers two adjacent amino acids at two ends of each peptide bond with the backbone directionality from the N-terminal to the C-terminal. The score is a corresponding propensity for a directional alignment of two adjacent amino acids with their local environments. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
