Chromatographic Separation of Puberty Accelerating Pheromone from Male Mouse Urine1

Autor:	Walter J. Dobrogosz, Steven S. Dills, Thomas A. Kost, John G. Vandenbergh, J. S. Finlayson
Rok vydání:	1976
Předmět:	medicine.medical_specialty medicine.medical_treatment Cell Biology General Medicine Urine Biology Ultrafiltration (renal) Endocrinology Reproductive Medicine Sephadex Internal medicine medicine Mouse Urine Pheromone Endocrine system Dialysis Hormone
Zdroj:	Biology of Reproduction. 15:260-265
ISSN:	1529-7268 0006-3363
DOI:	10.1095/biolreprod15.2.260
Popis:	Isolation of the pheromone in male mouse urine that is responsible f or accelerating female puberty is reported. Dialysis ultrafiltration and chromatography produced several fractions all of which were capable of hastening the onset of puberty in females. The lowest weight fraction on Sephadex G-15 was analyzed by chromatography revealing several fractions of which only 1 was active. The active fraction was found to have a molecular weight of 860 and contained no active steroids though had a strongly positive test for peptides. The manner in which male mouse urine stimulates sexual development in the female is not yet known though it appears that direct physical contact with the urine by the female may be required.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::393a26de0e90ac725a9ef1ae33e6a3f0 https://doi.org/10.1095/biolreprod15.2.260 Zobrazit plný text záznamu