B-Type Natriuretic Peptide Receptor Expression and Activity Are Hormonally Regulated in Rat Ovarian Cells1

Autor:	Jolanta Gutkowska, Riaz Farookhi, Alfred Noubani
Rok vydání:	2000
Předmět:	endocrine system medicine.medical_specialty medicine.drug_class Granulosa cell Estrogen analog Biology NPR1 Brain natriuretic peptide NPR2 Endocrinology Internal medicine Natriuretic peptide medicine Gonadotropin Receptor hormones hormone substitutes and hormone antagonists
Zdroj:	Endocrinology. 141:551-559
ISSN:	1945-7170 0013-7227
DOI:	10.1210/endo.141.2.7305
Popis:	Natriuretic peptides form a family of structurally related peptides known to regulate salt and water homeostasis and to cause vasodilation. Synthesis of atrial (ANP), brain (BNP), and C-type (CNP) natriuretic peptides occurs mainly in the heart and brain and has been identified recently in the female reproductive tract. The expression of ANP and CNP as well as their cognate guanylyl cyclase receptors (NPR-A and NPR-B, respectively) have been detected in the rat ovary. We have shown previously that the expression of the natriuretic peptides and their receptors in the rat ovary appears to be modulated by the estrous cycle. In the present study we have evaluated the expression of the natriuretic peptide system (peptide and receptor) in ovarian cells (granulosa and thecal-interstitial cells) obtained from immature female rats treated with either diethylstilbestrol (DES), an estrogen analog, or equine CG (eCG), a gonadotropin that possesses both LH and FSH activity. Using a whole cell RRA, we found that CNP bi...
Databáze:	OpenAIRE
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