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Summary Clinically significant interactions are most likely to occur between drugs that have potent effects, a narrow therapeutic range, and a steep dose-response curve.3 The treating oral and maxillofacial surgeon should know his or her patients' total drug intake (i.e., drugs prescribed by other practitioners, and all over-the-counter drugs, and, any herbal preparations). The effects of all drugs (including unwanted side effects) must be considered when a new medication is being added to a patients' existing regimen. The oral and maxillofacial surgeon should be cognizant that drug interactions may be the cause of an unexpected or unexplainable problem in his or her patient and be willing to address it. The authors have included several “quick reference tables” that provide useful information for clinical practice (Tables 1–12). The tables list drug interactions for medications with which the oral and maxillofacial surgeon may common into contact. These tables are by no means complete, and the reader who is interested in drug interactions should consult other sources: (1) Clinical Pharmacology Online: http://www.imc.gsm.com (select Drug Interactions) and (2) Medscape: http://www.medscape.com . |
