Antigen-specific suppression of type II collagen-induced arthritis by collagen-coupled spleen cells

Autor:	R T Schoen, M I Greene, D E Trentham
Rok vydání:	1982
Předmět:	Immunology Immunology and Allergy
Zdroj:	The Journal of Immunology. 128:717-719
ISSN:	1550-6606 0022-1767
Popis:	The induction of arthritis in Wistar-Lewis rats was suppressed by i.v. injections of spleen cells coupled to native type II collagen, beginning 14 days before intradermal injection of native type II collagen in incomplete Freund's adjuvant and continuing at 7-day intervals for the next 3 weeks. Cells coupled to native type I collagen or to denatured type II collagen were ineffectual, suggesting antigen-relevant cells were required for suppression. The phenomenon appeared to be mediated by a humoral effector mechanism; IgG antibody titers but not hemagglutinating antibody titers or delayed-type hypersensitivity to collagen were decreased by the injection of type II collagen-coupled cells. These data demonstrate the potential of antigen-specific immunotherapy for autoimmune disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::392212ead2a5ea4cd6b4e865545a862f https://doi.org/10.4049/jimmunol.128.2.717 Zobrazit plný text záznamu