RETRACTED ARTICLE: Cervical adenosquamous carcinoma: detailed analysis of morphology, immunohistochemical profile, and clinical outcomes in 59 cases
| Autor: | Lien Hoang, Iulia Barsan, Kay J. Park, Simona Stolnicu, Sarit Aviel-Ronen, Takako Kiyokawa, Cristina Terinte, Isabel Alvarado-Cabrero, Anna Pesci, Esther Oliva, Orsolya Hankó-Bauer, Robert A. Soslow |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Adenosquamous carcinoma business.industry Squamous Differentiation medicine.disease Cervical Adenosquamous Carcinoma Squamous metaplasia Glandular Differentiation 3. Good health Pathology and Forensic Medicine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Immunophenotyping 030220 oncology & carcinogenesis medicine Carcinoma PAX8 business |
| Zdroj: | Modern Pathology. 32:269-279 |
| ISSN: | 0893-3952 |
| DOI: | 10.1038/s41379-018-0123-6 |
| Popis: | Although 2014 World Health Organization criteria require unequivocal glandular and squamous differentiation for a diagnosis of cervical adenosquamous carcinoma, in practice, adenosquamous carcinoma diagnoses are often made in tumors that lack unequivocal squamous and/or glandular differentiation. Considering the ambiguous etiologic, morphological, and clinical features and outcomes associated with adenosquamous carcinomas, we sought to redefine these tumors. We reviewed slides from 59 initially diagnosed adenosquamous carcinomas (including glassy cell carcinoma and related lesions) to confirm an adenosquamous carcinoma diagnosis only in the presence of unequivocal malignant glandular and squamous differentiation. Select cases underwent immunohistochemical profiling as well as human papillomavirus (HPV) testing by in situ hybridization. Of the 59 cases originally classified as adenosquamous carcinomas, 34 retained their adenosquamous carcinoma diagnosis, 9 were reclassified as pure invasive stratified mucin-producing carcinomas, 10 as invasive stratified mucin-producing carcinomas with other components (such as HPV-associated mucinous, usual-type, or adenosquamous carcinomas), and 4 as HPV-associated usual or mucinous adenocarcinomas with benign-appearing squamous metaplasia. Two glassy cell carcinomas were reclassified as poorly differentiated usual-type carcinomas based on morphology and immunophenotype. There were significant immunophenotypic differences between adenosquamous carcinomas and pure invasive stratified mucin-producing carcinomas with regard to HPV (p |
| Databáze: | OpenAIRE |
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