Evidence for oxidative damage in a murine leukemia virus-induced neurodegeneration
| Autor: | Natalie V. Dugger, Paul M. Hoffman, Susan G. Wilt, Nancy D. Hitt |
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| Rok vydání: | 2000 |
| Předmět: |
Pathology
medicine.medical_specialty Microglia biology Central nervous system Neurodegeneration Neuropathology medicine.disease biology.organism_classification Pathogenesis Lipid peroxidation Cellular and Molecular Neuroscience chemistry.chemical_compound medicine.anatomical_structure Gliosis chemistry Murine leukemia virus Immunology medicine medicine.symptom |
| Zdroj: | Journal of Neuroscience Research. 62:440-450 |
| ISSN: | 1097-4547 0360-4012 |
| DOI: | 10.1002/1097-4547(20001101)62:3<440::aid-jnr14>3.0.co;2-m |
| Popis: | Vacuolation in cellular organelles within the central nervous system is a common manifestation of oxidative injury. We found that the spongiform vacuolation observed in PVC-211 murine leukemia virus (PVC-MuLV) neurodegeneration was associated with oxidative damage as detected by immunoreactivity for 3-nitrotyrosine and protein carbonyl groups. This oxidative injury was present in brain before or concomitant with the appearance of activated microglia, vacuolation, and gliosis that characterize PVC-MuLV neuropathology. Treatment of infected F344 rat pups with the antioxidant vitamin E transiently protected and prolonged the latency of PVC-MuLV neurodegeneration. Taken together, these findings implicate oxidative damage and lipid peroxidation in the pathogenesis of PVC-MuLV neurodegeneration. This animal model may be useful for studies of mechanisms and potential therapies for progressive neurodegeneration following a well-defined insult. |
| Databáze: | OpenAIRE |
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